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Stable, polyvalent aptamer-conjugated near infrared fluorescent nanocomposite for high-performance cancer cell-targeted imaging and therapy

Abstract

Early diagnosis and targeted therapy are two important ways to improve cancer treatment survival. In this work, via a simple DNA hybridization reaction, a DNA-templated fluorescent silver nanoclusters was successfully assembled around a DNA-modified gold nanoparticle (AuNP) to construct a novel nanocomposite with the functions of cancer cell-specific imaging and targeted therapy. As-prepared AuNP@(AS1411-AgNCs)n nanocomposite shows strong near-infrared fluorescence emission, improved biostability and carries a high density of AS1411, the first anticancer aptamer targeting at nucleolin protein that is over-expressed not only on the surface but also in the cytoplasm of cancer cells. The synergy of multivalent AS1411-nucleolin binding promotes the accumulation of the nanocomposite towards cancer cells and subsequent internalization in them. As results, highly specific cancer cell-targeted imaging and selective killing can be achieved in a low AuNP@(AS1411-AgNCs)n concentration range. The prepared nanocomposite also shows great potential as a carrier of doxorubicin to further promote the selective killing of cancer cells.

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Publication details

The article was received on 18 Aug 2017, accepted on 06 Nov 2017 and first published on 07 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB02218B
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Stable, polyvalent aptamer-conjugated near infrared fluorescent nanocomposite for high-performance cancer cell-targeted imaging and therapy

    Y. Zhu, W. Li, Z. Hong, A. Tang and D. Kong, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02218B

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