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A redox-responsive folate–fluorophore conjugate as a new target-cell-specific imaging probe

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Abstract

Here we have developed a redox-responsive folate–fluorophore conjugate (RFC) with a disulfide linker for the target-specific imaging of cancers. The quenched fluorescence of the RFC could be turned on after folate receptor-mediated endocytosis and subsequent cleavage of the disulfide linker by intracellular glutathione, enabling target-cell-specific fluorescence imaging with a high target-to-background ratio.

Graphical abstract: A redox-responsive folate–fluorophore conjugate as a new target-cell-specific imaging probe

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Publication details

The article was received on 14 Aug 2017, accepted on 26 Oct 2017 and first published on 30 Oct 2017


Article type: Communication
DOI: 10.1039/C7TB02180A
Citation: J. Mater. Chem. B, 2017, Advance Article
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    A redox-responsive folate–fluorophore conjugate as a new target-cell-specific imaging probe

    J. Kim, H. Kim and Y. Choi, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB02180A

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