Jump to main content
Jump to site search


Wide-range pKa tuning of proton imprinted nanoparticles for reversible protonation of target molecules via thermal stimuli

Author affiliations

Abstract

pKa tuning of Brønsted acids in synthetic nano-materials is of great importance for the design of ion exchange and bio-/molecular-separation media and polymer catalysis. It has been reported that hydrogel nanoparticles with carboxylic acids that show large and reversible pKa shifts in response to thermal stimuli can be prepared by copolymerization of N-isopropylacrylamide (NIPAm), acrylic acids (AAc) and N,N′-methylene bisacrylamide (BIS) via the proton imprinting polymerization process. However, the reported range of pKa shifts is limited to the range of 5.3 to 7.5. In this study, we report a procedure to prepare proton imprinted NPs that show pKa shifts in the tuned pKa range and demonstrate applications of the NPs. pKa values ranging from 4.3 to 8.7 were achieved by designing the structure of monomers containing carboxylic acids and applying the proton imprinting procedure. It was demonstrated that proton-imprinted NPs with different pKa values could be used for the reversible and selective protonation of target molecules which have specific pKa values. Our results establish the generality of the proton imprinting procedure and provide a guide for designing stable and inexpensive materials for sophisticated purification processes.

Graphical abstract: Wide-range pKa tuning of proton imprinted nanoparticles for reversible protonation of target molecules via thermal stimuli

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Aug 2017, accepted on 07 Nov 2017 and first published on 07 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB02107K
Citation: J. Mater. Chem. B, 2017, Advance Article
  •   Request permissions

    Wide-range pKa tuning of proton imprinted nanoparticles for reversible protonation of target molecules via thermal stimuli

    Y. Hoshino, T. Miyoshi, M. Nakamoto and Y. Miura, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB02107K

Search articles by author

Spotlight

Advertisements