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Design and preparation of 90Y-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications

Abstract

Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed the binding of the radionuclide 90Y to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The obtained values for the specific power absorption of MNPs (46.95–80.76 W/g) in different physiological media indicated their possible application for hyperthermia treatment. Both types of coated MNPs were 90Y-labeled in a reproducible high yield (>98 %). In vitro studies of 90Y-MNP in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that 90Y–Fe3O4–IDP and 90Y–Fe3O4–IHP MNPs were predominantly found in the liver (85.21 %ID and 86.22 %ID), followed by the spleen (9.23 %ID and 8.82 %ID) and the lungs (1.53 %ID and 1.53 %ID), respectively. The results of this comprehensive study showed the great promise of radiolabeled biocompatible phosphate magnetic complexes for therapeutic uses combining magnetic hyperthermia and radiotherapy.

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Publication details

The article was received on 02 Aug 2017, accepted on 11 Oct 2017 and first published on 11 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB02075A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Design and preparation of 90Y-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications

    M. Ž. Radović, M. D. Mirković, M. Peric, D. Jankovic, A. A. Vukadinović, D. Stanković, Đ. Petrović, M. Bošković, B. Antic, M. Marković and S. Vranješ Djurić, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02075A

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