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Au–Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

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Abstract

We report a delivery system based on Au–mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetylthiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.

Graphical abstract: Au–Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

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Publication details

The article was received on 31 Jul 2017, accepted on 05 Aug 2017 and first published on 07 Aug 2017


Article type: Communication
DOI: 10.1039/C7TB02045G
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Au–Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

    A. Llopis-Lorente, B. de Luis, A. García-Fernández, P. Díez, A. Sánchez, M. Dolores Marcos, R. Villalonga, R. Martínez-Máñez and F. Sancenón, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB02045G

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