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Lanthanide-doped bismuth oxobromide nanosheets for self-activated photodynamic therapy

Abstract

Low tissue penetration depth of excited light and complicated synthetic procedure greatly hinder the clinic application of photodynamic therapy (PDT). Here we present a facile and mass production route to fabricate Yb3+/Tm3+ co-doped BiOBr nanosheets. Different from the complicated carrier combining photosensitizers (PSs) with up-conversion nanoparticles (UCNPs), which generates PDT effect by fluorescence resonance energy transfer (FRET) process from UCNPs to PSs upon near-infrared light excitation, this as-synthesized material can be self-activated by deep-penetrated 980 nm laser to produce a large amount of reactive oxygen species (ROS), giving rise to high PDT efficiency which has been proved by in vitro and in vivo therapeutic assay. Surface modification of the BiOBr:Yb,Tm nanosheets with polyethylene glycol (PEG) endows the system with improved biocompatibility. Combing the inherent fluorescence and CT imaging properties, an imaging monitored therapeutic system has been realized. The system overcomes the problem of low tissue penetration depth and complicated structure induced low efficiency and potential safety concern. Our finding presents the first demonstration of self-activated nanoplatform for targeting and noninvasive deep-cancer therapy.

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Publication details

The article was received on 25 Jul 2017, accepted on 09 Sep 2017 and first published on 13 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01983A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Lanthanide-doped bismuth oxobromide nanosheets for self-activated photodynamic therapy

    L. Xu, F. He, C. Wang, S. Gai, A. Gulzar, D. Yang, C. zhong and P. yang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01983A

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