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Issue 39, 2017
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Lanthanide-doped bismuth oxobromide nanosheets for self-activated photodynamic therapy

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Abstract

Low tissue penetration depth of the excited light and complicated synthetic procedures greatly hinder the clinical application of photodynamic therapy (PDT). Here we present a facile and mass production route to fabricate Yb3+/Tm3+ co-doped BiOBr nanosheets. In contrast to the complicated combination of photosensitizers (PSs) with up-conversion nanoparticles (UCNPs), which generates a PDT effect by a fluorescence resonance energy transfer process from UCNPs to PSs upon near-infrared light excitation, this as-synthesized material can be self-activated by deep-penetrating 980 nm laser light to produce a large amount of reactive oxygen species, giving rise to a high PDT efficiency which has been proven by in vitro and in vivo therapeutic assays. Surface modification of the BiOBr:Yb,Tm nanosheets with polyethylene glycol endows the system with improved biocompatibility. Through the combination of inherent fluorescence and CT imaging properties, an imaging-monitored therapeutic system has been realized. The system overcomes the problems of low tissue penetration depth, complicated structure-induced low efficiency, and potential safety concerns. Our finding presents the first demonstration of a self-activated nanoplatform for targeted and noninvasive deep-cancer therapy.

Graphical abstract: Lanthanide-doped bismuth oxobromide nanosheets for self-activated photodynamic therapy

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Publication details

The article was received on 25 Jul 2017, accepted on 09 Sep 2017 and first published on 13 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01983A
Citation: J. Mater. Chem. B, 2017,5, 7939-7948
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    Lanthanide-doped bismuth oxobromide nanosheets for self-activated photodynamic therapy

    L. Xu, F. He, C. Wang, S. Gai, A. Gulzar, D. Yang, C. Zhong and P. Yang, J. Mater. Chem. B, 2017, 5, 7939
    DOI: 10.1039/C7TB01983A

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