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Issue 42, 2017
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A poly(ε-caprolactone)–poly(glycerol)–poly(ε-caprolactone) triblock copolymer for designing a polymeric micelle as a tumor targeted magnetic resonance imaging contrast agent

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Abstract

Gadolinium-based macromolecular contrast agents (CAs) with favorable biocompatibility, targeting specificity, and high relaxivity properties are desired for magnetic resonance imaging (MRI) of tumors. Herein, a novel triblock polymeric micelle based on poly(glycerol) (PG) and poly(ε-caprolactone) (PCL) was designed as a nanocarrier to fabricate a tumor targeted contrast agent (CA). Through conjugating gadolinium chelates and folic acid (FA) molecules to the PG block, a triblock-micelle contrast agent (T-micelle) formed from self-assembly demonstrated a low critical micelle concentration (CMC) of 6 mg L−1 and a hydrodynamic diameter of about 250 nm. Compared with small-molecule CAs, the T-micelle exhibited a higher longitudinal relaxivity (r1) of 14.71 mM−1 s−1. Moreover, the cellular viability assay revealed negligible cytotoxicity, and estimation of targeting capacity showed significant targeting specificity to tumor cells. In addition, MRI on tumor-bearing mice confirmed that the T-micelle could efficiently accumulate at the tumor region through targeting specificity and provide obvious contrast enhancement. Consequently, the T-micelle is a promising gadolinium-based macromolecular CA for tumor diagnosis.

Graphical abstract: A poly(ε-caprolactone)–poly(glycerol)–poly(ε-caprolactone) triblock copolymer for designing a polymeric micelle as a tumor targeted magnetic resonance imaging contrast agent

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Publication details

The article was received on 21 Jul 2017, accepted on 03 Oct 2017 and first published on 04 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01967J
Citation: J. Mater. Chem. B, 2017,5, 8408-8416
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    A poly(ε-caprolactone)–poly(glycerol)–poly(ε-caprolactone) triblock copolymer for designing a polymeric micelle as a tumor targeted magnetic resonance imaging contrast agent

    Y. Cao, M. Liu, Y. Kuang, G. Zu, D. Xiong and R. Pei, J. Mater. Chem. B, 2017, 5, 8408
    DOI: 10.1039/C7TB01967J

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