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Poly(ε-caprolacton)-poly(glycerol)-poly(ε-caprolacton) Triblock Copolymer for Designing Polymeric Micelle as Tumor Targeted Magnetic Resonance Imaging Contrast Agent

Abstract

Gadolinium-based macromolecular contrast agents (CAs) with favorable biocompatibility, targeting specificity, and high relaxivity properties are desired in magnetic resonance imaging (MRI) of tumor. Herein, the novel triblock polymeric micelle based on poly(glycerol) (PG) and poly(ε-caprolacton) (PCL) was designed as a nanocarrier to fabricate the tumor targeted contrast agent (CA). Through conjugating gadolinium chelates and folic acid (FA) molecules to PG block, the triblock-micelle contrast agent (T-micelle) formed from self-assembly demonstrated a low critical micelle concentration (CMC) of 6 mg/L and a hydrodynamic diameter of about 250 nm. Compared with small-molecule CAs, T-micelle exhibited a higher longitudinal relaxivity (r1) of 14.71 mM-1s-1. Moreover, cellular viability assay revealed negligible cytotoxicity, and estimation of targeting capacity showed significant targeting specificity to tumor cells. In addition, MRI on tumor-bearing mice confirmed that T-micelle could efficiently accumulate at tumor region through targeting specificity and provide obvious contrast enhancement. Consequently, T-micelle is a promising gadolinium-based macromolecular CA for tumor diagnosis.

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Publication details

The article was received on 21 Jul 2017, accepted on 03 Oct 2017 and first published on 04 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01967J
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Poly(ε-caprolacton)-poly(glycerol)-poly(ε-caprolacton) Triblock Copolymer for Designing Polymeric Micelle as Tumor Targeted Magnetic Resonance Imaging Contrast Agent

    Y. Cao, M. Liu, Y. Kuang, G. Zu, D. Xiong and R. Pei, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01967J

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