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Issue 43, 2017
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Fabrication of multifunctional ferric oxide nanoparticles for tumor-targeted magnetic resonance imaging and precise photothermal therapy with magnetic field enhancement

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Abstract

In this study, a biocompatible nanotheranostic platform (termed as Fe2O3@PDA-affibody) has been constructed on the basis of coating a near-infrared light (NIR)-absorbing polydopamine (PDA) shell on oleic acid-capped superparamagnetic ferric oxide nanoparticles (Fe2O3 NPs) using the water-in-oil microemulsion method and then conjugated with affibody ZIGF1R:4551, a peptide with high affinity to tumor and a polyethylene glycol (PEG) stabilizer. The Fe2O3@PDA-affibody integrates T2-weighted magnetic resonance imaging (MRI), tumor-targeting, and magnetic field (MF)-enhanced photothermal therapy (PTT) functionalities into an all-in-one system. The Fe2O3@PDA-affibody shows high negative contrast in the MRI of an SW620 tumor bearing mouse with a decrease of 68% MRI signal, indicating that the Fe2O3@PDA-affibody can recognize tumor with high efficacy and specificity. Furthermore, a high accumulation ratio (>13.5% ID gāˆ’1) and enhanced inhibition of tumor growth are achieved under near-infrared (NIR) (808 nm) laser irradiation with the aid of an external MF focused on the targeted tumor, resulting in complete eradication of mouse-borne SW620 tumors without regrowth.

Graphical abstract: Fabrication of multifunctional ferric oxide nanoparticles for tumor-targeted magnetic resonance imaging and precise photothermal therapy with magnetic field enhancement

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Publication details

The article was received on 21 Jul 2017, accepted on 04 Oct 2017 and first published on 04 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01959A
Citation: J. Mater. Chem. B, 2017,5, 8554-8562
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    Fabrication of multifunctional ferric oxide nanoparticles for tumor-targeted magnetic resonance imaging and precise photothermal therapy with magnetic field enhancement

    J. Liu, H. Chen, Y. Fu, X. Li, Y. Chen, H. Zhang and Z. Wang, J. Mater. Chem. B, 2017, 5, 8554
    DOI: 10.1039/C7TB01959A

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