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Fabrication of multifunctional ferric oxide nanoparticle for tumor-targeted magnetic resonance imaging and precise photothermal therapy with magnetic field enhancement

Abstract

In this study, a biocompatible nanotheranostic platform (termed as Fe2O3@PDA-affibody) has been constructed on the basis of coating a near-infrared light (NIR)-absorbing polydopamine (PDA) shell on oleic acid-capped superparamagnetic ferric oxide nanoparticle (Fe2O3 NP) via water-in-oil microemulsion method and then conjugated with affibody ZIGF1R:4551, a peptide with high affinity to tumor and a polyethylene glycol (PEG) stabilizer. The Fe2O3@PDA-affibody integrates T2-weighted magnetic resonance imaging (MRI), tumor-targeting, and magnetic field (MF)-enhanced photothermal therapy (PTT) functionalities into an all-in-one system. The Fe2O3@PDA-affibody shows high negative contrast in MRI of SW620 tumor bearing mouse with decreasing of 68% MRI signal, indicating that the Fe2O3@PDA-affibody can recognize tumor with high efficacy and specificity. Furthermore, high accumulation ratio ( 13.5 % ID g-1) and enhanced inhibition of tumor growth are achieved under near-infrared (NIR) (808 nm) laser irritation with the aid of an external MF focus on the targeted tumor, resulting in completely eradicated mouse-bearing SW620 tumor without regrowth.

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Publication details

The article was received on 21 Jul 2017, accepted on 04 Oct 2017 and first published on 04 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01959A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Fabrication of multifunctional ferric oxide nanoparticle for tumor-targeted magnetic resonance imaging and precise photothermal therapy with magnetic field enhancement

    J. Liu, H. Chen, Y. Fu, X. Li, Y. Chen, H. Zhang and Z. Wang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01959A

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