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Functionalized nanoceria exhibit improved angiogenic properties

Abstract

The growth of new blood vessels from pre-existing vasculature known as angiogenesis, has a vital importance in various physiological and pathological processes. In the present report, we demonstrate the pro-angiogenic properties of the functional nanoconjugates of organosilane functionalized cerium oxide (CeO2) nanoparticles (nanoceria). Aqueous dispersible CeO2 and trivalent metal (samarium) ion doped CeO2 (SmCeO2) nanoparticles conjugated with hydrophilic biocompatible and antifouling (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane moieties were prepared. The functional nanoconjugates were prepared via in situ synthesis and functionalization procedure using ammonia-induced ethylene glycol-assisted precipitation method. The prepared nanoconjugates were thoroughly characterized using various physico-chemical techniques such as transmission electron microscopy (TEM), X-Ray diffraction (XRD) analysis, dynamic light scafttering (DLS) and 13C high-resolution solid-state nucleare magnetic resonance (NMR). Pro-angiogenic properties of the prepared nanoconjugates were evaluated by employing various angiogenesis assays (in vitro and in vivo). The results of the present study illustrate that the functional nanoconjugates of SmCeO2 triggered the endothelial cell proliferation and induced the growth of blood vessels in chick embryo. The enhanced expression of pro-angiogenic markers (p38MAPK/ HIF-1α) by these functional nanoconjugates might be the plausible signaling mechanism underlying their pro-angiogenic property. Considering all the observations, we believe that the (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane conjugated SmCeO2 nanoparticles could be developed as potential candidates for the treatment of cardiovascular, ischemic and ocular diseases, where angiogenesis is the principal phenomenon.

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Publication details

The article was received on 21 Jul 2017, accepted on 08 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB01957B
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Functionalized nanoceria exhibit improved angiogenic properties

    S. K. Nethi, H. S. Nanda, W. J. Steele and C. Patra, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01957B

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