Jump to main content
Jump to site search

Issue 43, 2017
Previous Article Next Article

Towards improved HIV-microbicide activity through the co-encapsulation of NRTI drugs in biocompatible metal organic framework nanocarriers

Author affiliations

Abstract

The efficacy of the routinely used anti-HIV (Human Immunodeficiency Virus) therapy based on nucleoside reverse transcriptase inhibitors (NRTIs) is limited by the poor cellular uptake of the active triphosphorylated metabolites and the low efficiency of intracellular phosphorylation of their prodrugs. Nanoparticles of iron(III) polycarboxylate Metal–Organic Frameworks (nanoMOFs) are promising drug nanocarriers. In this study, two active triphosphorylated NRTIs, azidothymidine triphosphate (AZT-Tp) and lamivudine triphosphate (3TC-Tp), were successfully co-encapsulated into the biocompatible mesoporous iron(III) trimesate MIL-100(Fe) nanoMOF in order to improve anti-HIV therapies. The drug loaded nanoMOFs could be stored for up to 2-months and reconstituted after freeze drying, retaining similar physicochemical properties. Their antiretroviral activity was evidenced in vitro on monocyte-derived macrophages experimentally infected with HIV, making these co-encapsulated nanosystems excellent HIV-microbicide candidates.

Graphical abstract: Towards improved HIV-microbicide activity through the co-encapsulation of NRTI drugs in biocompatible metal organic framework nanocarriers

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Jul 2017, accepted on 29 Sep 2017 and first published on 29 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01933E
Citation: J. Mater. Chem. B, 2017,5, 8563-8569
  •   Request permissions

    Towards improved HIV-microbicide activity through the co-encapsulation of NRTI drugs in biocompatible metal organic framework nanocarriers

    M. T. Marcos-Almaraz, R. Gref, V. Agostoni, C. Kreuz, P. Clayette, C. Serre, P. Couvreur and P. Horcajada, J. Mater. Chem. B, 2017, 5, 8563
    DOI: 10.1039/C7TB01933E

Search articles by author

Spotlight

Advertisements