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Issue 40, 2017
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Fabrication of complex-shaped hydrogels by diffusion controlled gelation of nanocellulose crystallites

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Abstract

In this study we investigated the fabrication of small hydrogel objects by the coordination-driven assembly of supramolecular rod-like crystallites of nanocellulose, using ionotropic gelation as a methodological approach and Ca2+ as a gelling agent. We proved that the gelation process is diffusion-mediated and fitting the equations modelling this process to the profile of the Ca2+ front, a Ca2+ diffusion coefficient in the incipient hydrogel of (4.5 ± 1.1) × 10−6 cm2 s−1 was calculated. At the steady-state a spatially homogeneous distribution of Ca2+-crosslinked sites in the hydrogel network was observed. External ionotropic gelation produced beads, wires or disks, while core–shell capsules were obtained by inverse ionotropic gelation. We demonstrated that equilibrium and dynamics of the distribution of Ca2+ offer the opportunity to design precisely the size and shape of these small hydrogel objects. In particular, the core size and the shell thickness of the capsules can be tailored under kinetic controlled conditions. The proposed approach, with supramolecular structures of the natural source as assembling components and the water-in-water fabrication process, is fast, simple, and requires only sustainable chemistry and is easily implementable in automatic microfluidic platforms.

Graphical abstract: Fabrication of complex-shaped hydrogels by diffusion controlled gelation of nanocellulose crystallites

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Publication details

The article was received on 14 Jul 2017, accepted on 14 Sep 2017 and first published on 15 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01899A
Citation: J. Mater. Chem. B, 2017,5, 8096-8104
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    Fabrication of complex-shaped hydrogels by diffusion controlled gelation of nanocellulose crystallites

    C. A. Maestri, P. Bettotti and M. Scarpa, J. Mater. Chem. B, 2017, 5, 8096
    DOI: 10.1039/C7TB01899A

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