Jump to main content
Jump to site search


Hollow mesoporous ZSM-5 zeolites/chitosan ellipsoids loaded with doxorubicin as pH-responsive drug delivery system against osteosarcoma

Abstract

The toxic risks and adverse effects of anticancer drugs on healthy tissues limited their wide clinical application. Herein, we for the first time fabricated hollow mesoporous ZSM-5/chitosan ellipsoids loaded with doxorubicin (HM-ZSM-5/CS/DOX) as pH-responsive drug delivery systems against osteosarcoma. The HM-ZSM-5 ellipsoids including hollow core and mesoporous shell could efficiently load DOX drugs with the loading efficiency of 95.8%. The CS layer was unifirmly distributed on the HM-ZSM-5 ellipsoids that contributed to the pH-responsive release of DOX drugs. The controlled DOX release kinetics from the HM-ZSM-5/CS/DOX ellipsoids was fitted well with the Korsmeyer-Peppas model. The HM-ZSM-5/CS/DOX ellipsoids exhibited good biocompatibility due to the low DOX release rate in the neutral media that simulated healthy tissues or blood. Moreover, the cellular uptake of the HM-ZSM-5/CS/DOX ellipsoids took place in tumor cells, and the quick release of DOX significantly promoted the apoptosis of MG63 cells. The levels of MDA, LDH and CK markers for the HM-ZSM-5/CS/DOX group were lower than those for the free DOX group, suggesting no systemic toxicity to heart. Therefore, the HM-ZSM-5/CS/DOX ellipsoids as novel pH-responsive drug delivery systems can effectively treat osteosarcoma without systemic toxicity.

Back to tab navigation

Publication details

The article was received on 07 Jul 2017, accepted on 02 Sep 2017 and first published on 04 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01830D
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
  •   Request permissions

    Hollow mesoporous ZSM-5 zeolites/chitosan ellipsoids loaded with doxorubicin as pH-responsive drug delivery system against osteosarcoma

    X. Wen, F. Yang, Q. Ke, X. xie and Y. Guo, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01830D

Search articles by author

Spotlight

Advertisements