Jump to main content
Jump to site search

Issue 46, 2017
Previous Article Next Article

Electrospun organic–inorganic nanohybrids as sustained release drug delivery systems

Author affiliations

Abstract

In this work, the non-steroidal anti-inflammatory drugs ibuprofen (ibu) and ketoprofen (ket), both poorly soluble in water, were first intercalated into layered double hydroxide (LDH) nanoparticles. The drug–LDH composites were then mixed with poly(ε-caprolactone) (PCL) at 5% and 10% w/w ratios and processed into fibers via electrospinning, yielding organic–inorganic nanohybrids. PCL/drug fibers were additionally prepared as controls. The average diameter of the fibers ranged from 400 to 1000 nm. The fibers are found to be smooth and cylindrical, with the LDH-containing systems having more homogenous fibers than those without the inorganic filler. From in vitro drug release tests, it was determined that more than 90% of the intercalated ibu and ket were released from the drug–LDH nanohybrids within the first 4 hours. Similarly, more than 60% of the incorporated drug was freed from the PCL/drug fibers in this time period. However, the release rates of both ibu and ket from the drug–LDH loaded PCL fibers were significantly slower. Only 44–48% of ibu was released from the PCL/ibu–LDH system after 5 days, while the amount released in the case of ket was 20–25%. In addition, drug release was still ongoing after 5 days for all the PCL/drug–LDH samples. These systems are thus proposed to have potential as implantable drug delivery systems.

Graphical abstract: Electrospun organic–inorganic nanohybrids as sustained release drug delivery systems

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Jul 2017, accepted on 08 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB01825H
Citation: J. Mater. Chem. B, 2017,5, 9165-9174
  • Open access: Creative Commons BY license
  •   Request permissions

    Electrospun organic–inorganic nanohybrids as sustained release drug delivery systems

    Y. Gao, T. W. Teoh, Q. Wang and G. R. Williams, J. Mater. Chem. B, 2017, 5, 9165
    DOI: 10.1039/C7TB01825H

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements