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Fabrication of membrane absorbers based on amphiphilic carbonaceous derivatives for selective endotoxin clearance

Abstract

In this study, several novel blend membranes based on ligands-immobilized amphiphilic carbonaceous particles (ACPs) and matrix polymer polyvinylidene fluoride (PVDF) were prepared by immersion phase inversion method. The effects of ACPs content on filtration performance of membrane were investigated. Endotoxin removal by blend membranes at different pH and ionic strength was analyzed and discussed. The results indicated that the use of ACPs not only achieved uniform and stable incorporation of water-soluble ligands into hydrophobic polymer membrane but also improved its filtration properties, including permeability, strength, hydrophilicity and antifouling ability. The blend membranes with the optimum particle content showed good performances in filtration and were highly effective in removing endotoxins from both buffer and protein solutions under properly chosen conditions. More than 99.8 % of endotoxin removal and more than 90 % of BSA recovery were achieved when 1 mg L-1 of BSA solution with 116 EU mL-1 of endotoxin content was treated at pH 4.7. All the above suggested that the carrier-dispersed method described herein was one of effective methods in constructing functionalized blend membrane absorbers.

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Publication details

The article was received on 01 Jul 2017, accepted on 15 Sep 2017 and first published on 15 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01778B
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Fabrication of membrane absorbers based on amphiphilic carbonaceous derivatives for selective endotoxin clearance

    Q. Wu, Y. Xu, K. Yang, H. Cui, Y. Chen, M. Wang, Q. Zhu, W. kang and C. Gao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01778B

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