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Litchi-like Fe3O4@Fe-MOF Capped with HAp Gatekeepers for pH-Triggered Drug Release and Anticancer Effect

Abstract

A novel litchi-like porous composite composed of a magnetic core, a tunable metal-organic framework (MOF) shell and pH-sensitive hydroxyapatite (HAp) gatekeeper was successfully fabricated in this work. The anti-cancer drug DOX was effectively loaded on Fe3O4@Fe-MOF@HAp nanocomposite with the drug loading capacity up to 32.96 μg/mg. The nanocomposite with the saturation magnetization of 34 emu/g possesses magnetic targeting function. In addition, the HAp gate with favorable biocompatibility and pH response characteristics could be used to control the release of loaded DOX from Fe3O4@Fe-MOF@HAp-DOX nanocomposite microspheres in the simulated acidic tumor cell environment, which could effectively kill tumor cells and reduce the toxic side effects on normal tissue. This study provides a smart design on the tunable shell and gate-controlled architectures for the sensitive release of drugs and efficient antitumor.

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Publication details

The article was received on 19 Jun 2017, accepted on 10 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01680H
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Litchi-like Fe3O4@Fe-MOF Capped with HAp Gatekeepers for pH-Triggered Drug Release and Anticancer Effect

    Y. Yang, F. Xia, Y. Yang, B. Gong, A. Xie, Y. Shen and M. Zhu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01680H

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