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Issue 43, 2017
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Litchi-like Fe3O4@Fe-MOF capped with HAp gatekeepers for pH-triggered drug release and anticancer effect

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Abstract

A novel litchi-like porous composite composed of a magnetic core, a tunable metal–organic framework (MOF) shell and a pH-sensitive hydroxyapatite (HAp) gatekeeper was successfully fabricated in this work. The anticancer drug doxorubicin (DOX) was effectively loaded on the Fe3O4@Fe-MOF@HAp nanocomposite with a loading capacity of 75.38 mg g−1. The nanocomposite had a saturation magnetization of 34 emu g−1 and thus possessed magnetic targeting function. In addition, the HAp gate, which had favorable biocompatibility and pH response characteristics, could be used to control the release of loaded DOX from the Fe3O4@Fe-MOF@HAp nanocomposite microspheres in a simulated acidic tumor cell environment, effectively killing tumor cells and reducing the toxic side effects to normal tissue. The smart design presented in this study, which incorporates a tunable shell and gate-controlled architecture, allows the sensitive release of drugs for efficient antitumor activity.

Graphical abstract: Litchi-like Fe3O4@Fe-MOF capped with HAp gatekeepers for pH-triggered drug release and anticancer effect

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Publication details

The article was received on 19 Jun 2017, accepted on 10 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01680H
Citation: J. Mater. Chem. B, 2017,5, 8600-8606
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    Litchi-like Fe3O4@Fe-MOF capped with HAp gatekeepers for pH-triggered drug release and anticancer effect

    Y. Yang, F. Xia, Y. Yang, B. Gong, A. Xie, Y. Shen and M. Zhu, J. Mater. Chem. B, 2017, 5, 8600
    DOI: 10.1039/C7TB01680H

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