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Synergistic photodynamic therapeutic effect of indole-3-acetic acid using pH sensitive nano-carrier based on poly(aspartic acid-graft-imidazole)-poly(ethylene glycol)

Abstract

A poly(aspartic acid-graft-imidazole)- poly(ethylene glycol) (P(Asp-g-Im)-PEG) was utilized as a pH-sensitive nanocarrier of a photosensitizer indole-3-acetic acid (IAA) for treatment of skin cancer. IAA loaded micelles (ILMs) exhibited formation of ca. 140 nm spherical particles at pH 7.4. The micelles disintegrated at acidic pHs, resulting in pH-dependent IAA release and cytotoxicity. Treatment of ILMs with visible light at a wavelength of 480 nm caused pH dependent synergistic cell damage in both in vitro and in vivo models using the B16F10 melanoma cell line. Interestingly, ILMs synergistically produced reactive oxygen species (ROS) at an acidic pH of 6.5 with visible light radiation by proton coupled electron transfers (PCET). The pH sensitive ILMs could be considered potent nanomedicine used to exert synergistic photodynamic therapeutic effects to treat cancers.

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Publication details

The article was received on 16 Jun 2017, accepted on 07 Oct 2017 and first published on 08 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01651D
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Synergistic photodynamic therapeutic effect of indole-3-acetic acid using pH sensitive nano-carrier based on poly(aspartic acid-graft-imidazole)-poly(ethylene glycol)

    T. Sim, C. Lim, N. H. Hoang, J. E. Kim, E. S. Lee, Y. S. Youn and K. T. Oh, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01651D

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