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Graphene quantum dots supported by graphene oxide as a sensitive fluorescence nanosensor for cytochrome c detection and intracellular imaging

Abstract

A new class of cytochrome c (Cyt c) detection fluorescence sensor (GQDs-GO) based on graphene quantum dots (GQDs) supported by graphene oxide (GO) has been developed through simply mixing a certain amount of GQDs and GO. It is found that fluorescence “turn on” or “turn off” can be adjusted easily according to the concentration of the Cyt c. For the Cyt c, whtn the concentration is lower than 1.9 μmolL-1, the fluorescence is “turn on”, while it is “turn off” beyond 1.9 μmolL-1. The process is fast and can be completed within 10 s. By means of UV-vis absorption spectrum, it is demonstrated that the changed fluorescence comes from the different interaction among GQDs, GO and Cyt c. Additionally, the GQDs-GO shows a high selectivity for Cyt c detection, and further exhibits favorable intracellular imaging in A549 cells. This study opens a new direction for developing a low-cost, highly efficient, GQDs-based fluorescence sensor for Cyt c detection, which made it very attractive for biological imaging applications.

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Publication details

The article was received on 14 Jun 2017, accepted on 14 Jul 2017 and first published on 14 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB01629H
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Graphene quantum dots supported by graphene oxide as a sensitive fluorescence nanosensor for cytochrome c detection and intracellular imaging

    L. Cao, X. Li, L. Qin, S. Kang and G. Li, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01629H

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