Jump to main content
Jump to site search

Issue 38, 2017
Previous Article Next Article

Fluorescent carbon dots from antineoplastic drug etoposide for bioimaging in vitro and in vivo

Author affiliations

Abstract

Carbon dots (CDs) hold great promise as a class of fluorophores for bioimaging. Here, we report a simple solvothermal approach to prepare photoluminescent CDs derived from the antineoplastic drug etoposide. The CDs show photoluminescence ranging from 365 to 650 nm when excited at 360 nm. When excited at 405, 488 and 543 nm, strong blue, green and red fluorescence can be detected. Our experiments reveal that the CDs can penetrate into the cells in a short time and remain emissive, even at low temperature. Also, optical signals can be detected from mice after hypodermic or intravenous injection. We demonstrated that the CDs can serve as a low-cytotoxicity biological imaging agent for bioimaging in vitro and in vivo.

Graphical abstract: Fluorescent carbon dots from antineoplastic drug etoposide for bioimaging in vitro and in vivo

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Jun 2017, accepted on 04 Aug 2017 and first published on 04 Aug 2017


Article type: Paper
DOI: 10.1039/C7TB01628J
Citation: J. Mater. Chem. B, 2017,5, 7796-7800
  •   Request permissions

    Fluorescent carbon dots from antineoplastic drug etoposide for bioimaging in vitro and in vivo

    B. Wu, R. Zhu, M. Wang, P. Liang, Y. Qian and S. Wang, J. Mater. Chem. B, 2017, 5, 7796
    DOI: 10.1039/C7TB01628J

Search articles by author

Spotlight

Advertisements