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Layer-by-layer assembling Cu3(BTC)2 on chitosan non-woven fabrics: A promising haemostatic decontaminant composite materials against sulfur mustard

Abstract

Cu3(BTC)2 (H3BTC = 1,3,5-benzenetricarboxylic acid) was anchored on the surface of carboxymethylated chitosan non-woven fabric by a controllable layer-by-layer technique in alternating solution baths of Cu(OAc)2•H2O and H3BTC solutions, and the resulting [Cu3(BTC)2]n@chitosan non-woven fabrics composite materials (n = the alter-native deposition times) was thoroughly characterized. The results showed that the composite materials not only ex-hibited excellent decontamination ability against sulfur mustard (HD) with enhanced degradation rate of HD by grow-ing number n, but also possessed remarkable haemostasis performance. The degradation efficiency for sulfur mustard by [Cu3(BTC)2]4@chitosan were found much higher than pristine [Cu3(BTC)2]4. The inherent hae-mostatic capabilities of chitosan non-woven fabrics was not affected by growth of Cu3(BTC)2 on the surface of chitosan. The oral and histological toxicity examinations of pristine Cu3(BTC)2 sample showed that damage and toxicity in each viscera of mice was very low even if intra-gastric administration dose of Cu3(BTC)2 reached to a very high level (50 mg of Cu3(BTC)2 per kg of mouse). The results have showed that the as-prepared composite can be used safely as a promis-ing haemostatic decontaminant with good recyclability against sulfur mustard.

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Publication details

The article was received on 02 Jun 2017, accepted on 14 Jul 2017 and first published on 14 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB01489A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Layer-by-layer assembling Cu3(BTC)2 on chitosan non-woven fabrics: A promising haemostatic decontaminant composite materials against sulfur mustard

    L. Zhang, J. Sun, Y. Zhou, Y. Zhong, Y. Ying, Y. Li, Y. Liu, Z. Zuhra and C. Huang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01489A

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