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A Low-Power White Light Triggered AIE Polymer Nanoparticles with High ROS Quantum Yield for Mitochondria-Targeted and Image-Guided Photodynamic Therapy

Abstract

Photodynamic therapy (PDT) has received enormous attention due to its high specificity in eliminating the malignant tumor cells without interposing normal cells, as compared with chemotherapy. In this work, we fabricated a mitochondria-targeting NPs using new AIE cross-linked copolymer (PAIE-TPP) with far red/near-infrared (FR/NIR) subcellular bioimaging ability and high reactive oxygen species (ROS) quantum yield of 77.9%. Such high efficient ROS generation is desirable to raise efficiency of PDT. The PAIE-TPP NPs possess great cytocompatibility but exert severe cytotoxicity to cancer cells with only 4% of the cell viability under an ultralow-power-intensity (10 mW cm-2) light irradiation. The AIE cross-linked copolymer NPs not only emits bright FR/NIR fluorescence for efficient in vitro subcellular-mitochondrial bioimaging but also generates high ROS for PDT.

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Publication details

The article was received on 28 May 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB01443K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    A Low-Power White Light Triggered AIE Polymer Nanoparticles with High ROS Quantum Yield for Mitochondria-Targeted and Image-Guided Photodynamic Therapy

    Y. Zheng, H. Lu, Z. Jiang, Y. Guan, J. Zou, X. Wang, R. Cheng and H. Gao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01443K

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