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Antiviral Activity of Self-Assembled Glycodendro[60]fullerene Monoadducts

Abstract

A series of amphiphilic glycodendro[60]fullerene monoadducts were efficiently synthesized using the CuAAC “click chemistry” approach. These glycodendrofullerenes can self-assemble in aqueous media, in a process favoured through π- π interactions between the [60]fullerene moieties. This aggregation process leads to big and well-defined compact micelles with a uniform size and spherical-shape. The supramolecular aggregate was characterized using electronic microscopy (SEM and TEM), light scattering methods (DLS) and X-ray methodologies (SAXS and XRD). The antiviral efficiency of these aggregates has been tested in an experimental infection assay using Ebola virus glycoprotein (EboGP) pseudotyped viral particles on Jurkat cells overexpressing DC-SIGN and it is observed an improvement of the IC50 value with respect to other systems endowed with a higher number of carbohydrate ligands

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Publication details

The article was received on 19 May 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01379E
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Antiviral Activity of Self-Assembled Glycodendro[60]fullerene Monoadducts

    A. Muñoz, I. M. Beatriz, J. Luczkowiak, F. Lasala, R. Ribeiro-Viana, J. Rojo, R. Delgado and N. Martín, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01379E

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