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Facile synthesis of a theranostic nanoparticle by oxidation of dopamine-DTPA-Gd conjugates

Abstract

Photothermal therapies (PPTs) with various light-absorbing materials have shown very promising therapeutic effects against cancers. However, their application were severely limited by lack of accurate localization of tumors and real-time monitoring of the therapeutic process. Theranostic nanoparticles with both imaging and therapeutic functions are highly desired to develop imaging-mediated PPTs. Herein, we develop a facile one-pot method to synthesize a nanoparticle with functions of MRI contrast agent and PTT agent through oxidization of dopamine-DTPA-Gd conjugates and PEG-dopamine conjugates. The oxidized dopamine nanoparticle (ODNP) had a high R1 up to 9.6 mM-1s-1, 2.2 times higher than that of Omniscan, and showed significant higher MRI contrast enhancement than Omniscan in tumor. Meanwhile, the ODNP showed strong NIR light absorption and significant antitumor efficacy both in vitro and in vivo as a PPT agent. The ODNP having excellent MRI contrasting capability and PTT efficacy plus its facile synthesis and good biocompatibility is a very promising theranostic agent for MRI-mediated PTT.

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Publication details

The article was received on 18 May 2017, accepted on 05 Oct 2017 and first published on 06 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB01362K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Facile synthesis of a theranostic nanoparticle by oxidation of dopamine-DTPA-Gd conjugates

    M. Xia, M. Ye, X. Zhou, J. Tang, Y. Piao, X. Liu, Z. Zhou, H. Hu and Y. Shen, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01362K

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