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Carbon quantum dots/block copolymer ensembles for metal-ion sensing and bioimaging


Fluorescent carbon quantum dots (CQDs) rich in amine moieties that can be easily protonated under acidic conditions were electrostatically interacted with diblock copolymer poly[sodium(carboxylate sulfamate) isoprene]-b-poly(ethylene oxide) (CSS-IEO-3) possessing negatively charged sulfamate and carboxylate species on the CSS part of the diblock copolymer. The so-formed CQDs/CSS-IEO-3 material was found to be stable in neutral and high salinity environment, which is critical when pointing to biological applications. Moreover, the photoluminescence of CQDs within CQDs/CSS-IEO-3, with emission at 420 nm upon excitation at 320 nm, was unaffected by pH and salinity changes, denoting the absence of significant aggregation phenomena and highlighting the potentiality of CQDs/CSS-IEO-3 for bioimaging. The photoluminescence of CQDs/CSS-IEO-3 was employed to develop a selective and sensitive method for the facile detection of Fe3+, in the presence of other metal salts, with a detection limit of 8.37 μM. Furthermore, integration of bovine serum albumin (BSA) furnished the three-component CQDs/CSS-IEO-3•BSA nanoensemble, without causing cytotoxicity when subjected to RKO human colon adenocarcinoma cells. Evidently, confocal fluorescence microscopy allowed the imaging of CQDs/CSS-IEO-3•BSA within living cells, and illustrated its application potential for bioimaging and drug delivery.

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Publication details

The article was received on 17 May 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017

Article type: Paper
DOI: 10.1039/C7TB01352C
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Carbon quantum dots/block copolymer ensembles for metal-ion sensing and bioimaging

    T. Skaltsas, M. Goulielmaki, A. Pintzas, S. Pispas and N. Tagmatarchis, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01352C

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