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Size- and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood-brain barrier

Abstract

Titanium dioxide nanoparticles (TiO2-NPs) have been found to translocate into the brain by penetrating the blood-brain barrier (BBB), but it remains largely unknown how their physicochemical characteristics may impact BBB permeabilization. By testing TiO2 particles of different shape in various size, we found that: 1) small, spherical TiO2-NPs permeabilized the BBB-like human brain microvasculature endothelial cell monolayer better than rod-like or large particles; 2) TiO2-NPs stimulated F-actin stress fiber formation, and induced paracellular gaps and ROCK II activation. TiO2-NP-mediated BBB permeabilization was associated with intracellular uptake and cytoskeletal re-organization; and 3) in the rat, spherical, small TiO2-NPs significantly increased the BBB permeability and entered the brain. TiO2-NPs were accumulated in the brain, but no obvious pathological anomaly was observed in the cerebral cortex and hippocampus. Our study investigated the neurotoxicity of TiO2-NPs, thereby providing scientific evaluation for the potential biomedical applications of TiO2-NPs.

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Publication details

The article was received on 14 May 2017, accepted on 26 Sep 2017 and first published on 26 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01314K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Size- and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood-brain barrier

    X. Liu, B. Sui and J. Sun, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01314K

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