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Repair of Volumetric Bone Defect with A High Strength BMP-Loaded-Mineralized Hydrogel Tubular Scaffold

Abstract

Efficient repair of critical-size volumetric bone defect remains a challenge due to the additional complicated surgery required for fixation. In this work, we first synthesized hydrogen bonding crosslinked supramolecular polymer (SP) hydrogels termed as P(NAGA-VPA) by copolymerizing two carefully selected monomers, N-acryloyl glycinamide (hydrogen bonding monomer) and vinylphosphonic acid (mineralization active monomer) directly in concentrated aqueous solution. The P(NAGA-VPA) hydrogels were then subjected to in situ precipitation mineralization to generate novel high strength mineralized SP hydrogels. The concerted dual physical crosslinkages of NAGA H-bonds and nanocrystal-polymer interaction led to the best comprehensive mechanical performances with over 1 MPa tensile strength and 5 MPa compressive strength in equilibrium swelling state. The mineralized SP hydrogel tubular scaffold was fabricated and encapsulated with bone morphogenetic protein-2 (BMP-2). The BMP-2-loaded mineralized SP hydrogel tube was finely sleeved over the murine radial defect without resorting to any additional surgical fixation. 8-weeks implantation outcome demonstrated that this hybrid tubular scaffold contributed to an efficient repair of volumetric bone defect by accelerating new bone formation and seamlessly bonding to the bone surface.

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Publication details

The article was received on 11 May 2017, accepted on 18 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01279A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Repair of Volumetric Bone Defect with A High Strength BMP-Loaded-Mineralized Hydrogel Tubular Scaffold

    X. Zhang, B. Xu, F. Gao, P. Zheng and W. Liu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01279A

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