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Near-Infrared Conjugated Polymers for Photoacoustic Imaging-Guided Photothermal/Chemo Combination Therapy

Abstract

Conjugated polymers (CPs) with intensive near-infrared (NIR) absorption and high photothermal conversion efficiency (PCE) have appeared as a new generation of photothermal therapy (PTT) and photoacoustic imaging (PAI) agents forcancer therapy. “PTT + chemotherapy” has been identified as powerful modality to offer synergistic effects in destroying and monitoring cancer tissues. In this work, diketopyrrolopyrrole-based polymers (DPP) are designed through combination of donor-acceptor moieties. Then doxorubicin (DOX) and DPP are co-encapsulated in tocopheryl polyethylene-glycol-succinate-cholesterol (TPGS-CHO) copolymers to build a combined theranostic system for tumor treatment. These combined NPs with high PCE (~50%) and strong (NIR) absorption exhibit excellent real-time photoacoustic imaging detection and synergistic cancer inhibition.

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Publication details

The article was received on 09 May 2017, accepted on 15 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01264K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Near-Infrared Conjugated Polymers for Photoacoustic Imaging-Guided Photothermal/Chemo Combination Therapy

    Y. Cao, Y. Wu, G. Wang, J. Yi, C. Yu, Y. Huang, L. Sun, Y. L. Bao and Y. Li, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01264K

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