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Issue 29, 2017
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Contrast agents for cardiovascular magnetic resonance imaging: an overview

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Abstract

Cardiovascular Magnetic Resonance (CMR), a non-invasive and nonionizing imaging technique, plays a major role in research and clinical cardiology. The strength of CMR lies in its high temporal resolution, superior contrast, and unique tissue characterization capabilities. Contrast agents have been used to improve sensitivity and specificity of CMR in detecting and evaluating various pathologies. Much effort has been made to develop more efficient contrast reagents to detect cardiovascular diseases at an asymptomatic stage, which has led to a plethora of products in animal studies. However, very few of the developed contrast agents are currently approved for human use. Major obstacles are high dosages, toxicity, body clearance rate and long-term immunogenicity. In this review, we critically assess recent developments in the field of the contrast agents for CMR, highlighting both benefits and current drawbacks. A clearer insight regarding the challenges facing the development of improved contrast agents may help collaborative work to enhance images contrast, decrease toxicity and accelerate their translation into clinical use.

Graphical abstract: Contrast agents for cardiovascular magnetic resonance imaging: an overview

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Publication details

The article was received on 07 May 2017, accepted on 04 Jul 2017 and first published on 04 Jul 2017


Article type: Review Article
DOI: 10.1039/C7TB01241A
Citation: J. Mater. Chem. B, 2017,5, 5714-5725
  • Open access: Creative Commons BY license
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    Contrast agents for cardiovascular magnetic resonance imaging: an overview

    M. M. Meloni, S. Barton, L. Xu, J. C. Kaski, W. Song and T. He, J. Mater. Chem. B, 2017, 5, 5714
    DOI: 10.1039/C7TB01241A

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