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Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

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Abstract

Phosphate-based bioactive glasses (PBGs) dissolve harmlessly in the body with a dissolution rate which depends sensitively on composition. This makes them proposed vectors for e.g. drug delivery, or other applications where an active component needs to be delivered at a therapeutically appropriate rate. Molecular dynamics (MD) simulations provide atomic-level structural information about PBG compositions. We review recent work to show that MD is an excellent tool to unravel the connections between the PBG glass composition, its atomic structure, and its dissolution rate, which can help to optimise PBGs for specific medical applications.

Graphical abstract: Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

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Publication details

The article was received on 06 May 2017, accepted on 15 Jun 2017 and first published on 15 Jun 2017


Article type: Review Article
DOI: 10.1039/C7TB01236E
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

    J. K. Christie, R. I. Ainsworth, S. E. R. Hernandez and N. H. de Leeuw, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB01236E

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