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Preparation of novel anionic polymeric ionic liquids materials and their potential in proteins adsorption

Abstract

In this article, a series of anionic polymeric ionic liquids (PILs) materials with high adsorption capacity to proteins were developed by using 2-acrylamido-2-methyl propane sulfonic acid imidazole derivative ([AMPS][RIm]) (R: -H, -C6H5, or -(CH2)3CH3) as the functional monomer. It’s the first time the anionic polymeric ionic liquids monomer (ILM) which included imidazole cations modified with alkyl derivative (butyl or phenyl groups) and sulphonic group functionalized anions was chosen as the only monomer to prepare materials for protein adsorption. The resultant anionic PILs materials were characterized by scanning electron microscope (SEM), fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimeter (DSC), and thermogravimetric analyses (TGA), respectively. Then, the adsorption behavior of the obtained anionic PILs material for proteins was evaluated. The results indicated that the anionic PILs material showed superior adsorption for proteins at different pHs: ovotransferrin (OVT, 861.5 mg g-1) and bovine serum albumin (BSA, 842.2 mg g-1) at pH 4.0; bovine hemoglobin (BHb, 983.4 mg g-1) and cytochrome c (Cytc, 882.9 mg g-1) at pH 7.0; casein (605.2 mg g-1) at pH 8.0, respectively. The feasibility of the resultant material for the separation of BHb from a real biological sample of bovine blood had also been demonstrated. The convenient preparation of the anionic PILs material as well as ultra high adsorption capacity for proteins predicted its attractive and broadly applicable potential in proteomics, medical diagnosis and sensors.

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Publication details

The article was received on 06 May 2017, accepted on 04 Jul 2017 and first published on 04 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB01234A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Preparation of novel anionic polymeric ionic liquids materials and their potential in proteins adsorption

    M. Dang, Q. Deng, G. Fang, D. Zhang, J. Liu and S. Wang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01234A

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