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Breaking the reduced glutathione-activated antioxidant defence for enhanced photodynamic therapy

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Abstract

Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species (ROSs) to kill cancer cells. However, a high concentration of reduced glutathione (GSH) is present in cancer cells and can consume ROSs and sharply reduce the PDT activity. To address this problem, herein, we synthesized a thymine modified Zn phthalocyanine (ZnPc, a monomer and an active form for PDT) and prepared its nanoparticle form (an aggregator and an inactive form) with Hg2+ providing the driving force for the “thymine–Hg2+–thymine” interaction. The nanoparticles could remain in the inactive form during the delivery process in blood. Once endocytosed by cancer cells, the nanoparticles are disintegrated, and deprived of Hg2+ by intracellular GSH, which decreases the level of GSH. Simultaneously, the activity of the released monomer ZnPc is recovered and high PDT activity is observed.

Graphical abstract: Breaking the reduced glutathione-activated antioxidant defence for enhanced photodynamic therapy

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Publication details

The article was received on 06 May 2017, accepted on 12 Jul 2017 and first published on 15 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB01233K
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Breaking the reduced glutathione-activated antioxidant defence for enhanced photodynamic therapy

    Q. Zhan, X. Shi, X. Yan, Q. Liu, J. Zhou, L. Zhou and S. Wei, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB01233K

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