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Dual responsive hydrogel based on functionalized mesoporous silica nanoparticles as an injectable platform for tumor therapy and tissue regeneration

Abstract

To achieve effective tumor therapy and regenerate new tissue from defects formed by tumor atrophy, a dual responsive hydrogel integrating stepwise delivery of anti-tumor drugs/growth factors and pH/thermo induced structure transformation is developed, based on polymer (poly N-isopropylacrylamide (PNIPAM) and polyacrylic acid (PAA)) functionalized mesoporous silica nanoparticles (MSNs). Due to the thermal responsive tangle between PNIPAM chains and the pH triggered hydrogen bonds in PAA chains, these injectable MSNs would immediately switch from nanoparticles to compact hydrogel in tumor environment (37.5℃, pH 6.8), where the concentrated network structure in hydrogel is in charge of loading and local delivery of anti-tumor drug. The MSNs serves as nanocarriers for growth factors, which is localized by the crosslinked network. The sustained release of growth factors only happened with cleavage of hydrogen bonds in PAA chains, which is triggered by the pH increase to 7.4 after cure of tumor. Moreover, the hydrogen bonds cleavage would also cause swelling of the hydrogel, which not only fill the defects but generate plenty of cell-level pores, resulting in an excellent scaffold for attachment and proliferation of healthy cells. Therefore, the dual responsive MSNs-hydrogel offered a promising strategy for sequential tumor therapy and tissue regeneration.

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Publication details

The article was received on 05 May 2017, accepted on 18 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01225J
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Dual responsive hydrogel based on functionalized mesoporous silica nanoparticles as an injectable platform for tumor therapy and tissue regeneration

    X. Chen, P. Yuan, Z. Liu, Y. Bai and Y. Zhou, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01225J

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