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Fluorinated carbon fiber as a novel nanocarrier for cancer chemo-photothermal therapy

Abstract

Although biomedical applications of carbon materials such as fullerene, carbon nanotubes and graphene have been intensively studied in recent years owing to their unique chemical and physical properties, fluorinated carbon fiber (FC) has been rarely explored in biomedicine, mostly because of it’s large-size, needle-like structure and strong hydrophobicity. In this work, for the first time we developed a novel FC-based nano-carrier with good biocompatibility, high drug-loading capacity and enhanced photo-thermal performance. A simple and feasible strategy is first employed to transform commercial FC into nano-sized ones with good solubility both in water and culture medium. The changes in surface wettability then facilitated us to load doxorubicin onto FC via π - π stacking interactions. Successful regulation of structure and composition also endows FC with enhanced photo-thermal response in near-infrared region. Moreover, cell experiment indicates that the constructed nanocarrier can be easily transferred into cells by endocytosis, showing low toxicity and exhibiting excellent cancer therapy effects resulting from a good combination of chemotherapy and photothermal therapy. Considering the low cost, high synthesis efficiency and outstanding properties of FC, the newly developed nanocarrier may find widespread application in biomedicine and other related fields.

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Publication details

The article was received on 27 Apr 2017, accepted on 03 Jul 2017 and first published on 03 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB01155E
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Fluorinated carbon fiber as a novel nanocarrier for cancer chemo-photothermal therapy

    L. Sun, P. Gong, X. Liu, M. Pang, J. Chen, M. Tian, Y. Zhang, J. Du and Z. Liu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01155E

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