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Ultrahigh-yield Synthesis of N-doped Carbon Nanodots with Down-regulating ROS in Zebrafish

Abstract

Oxidative damage induced by accumulation of excessive reactive oxygen species (ROS) could result in increased chronic inflammation and thus ageing and age-related diseases. Carbonaceous nanodrug holds great promise for ameliorating age-related diseases, where it is necessary to develop ultrahigh-yield synthesis of such nanodrug. To improve the synthetic yield (less than 50%) of carbon nanodots (CNDs), the general choice is to screen the precursor. Actually no reliable concept for improving yield is proposed over the past decades. We are first to propose the concept of carbon-carbon double bonds boosting synthetic yield and demonstrate record breaking ultrahigh-yield (85.9%) synthesis of N-doped CNDs. When C=C content increased from 14 to 56 mmol, synthetic yield exhibited 3.3-fold increase. The nitrogen elements are doped as pyridinic-like N and NH2, where conjugated π-system as electron donors and pyridinic-like structures would benefit the potential down-regulated effect for ROS. N-doped CNDs exhibit outstanding protective effect against oxidative stress via inhibiting exogenous and endogenous ROS generation, where the ROS in zebrafish is significantly reduced by 68%. Hence the concept of carbon-carbon double bonds boosting ultrahigh-yield synthesis of N-doped CNDs provides a promising strategy to be employed as carbonaceous nanodrug aiming at preventing and curing ageing and age-related diseases.

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Publication details

The article was received on 23 Apr 2017, accepted on 31 Aug 2017 and first published on 01 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB01114H
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Ultrahigh-yield Synthesis of N-doped Carbon Nanodots with Down-regulating ROS in Zebrafish

    L. Wang, B. Li, L. Li, F. Xu, Z. Xu, D. Wei, Y. Feng, Y. Wang, D. Jia and Y. Zhou, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01114H

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