Jump to main content
Jump to site search

Issue 32, 2017
Previous Article Next Article

Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

Author affiliations

Abstract

We present novel hollow carbon nanospheres (HCNs) for targeted breast cancer therapy. The HCNs have a 40 nm-cavity for drugs loading, and the surface is covered with “natural” primary amine without any exogenous modification, equipped to conjugate with functional biomolecules. After modification with anti-HER2 antibody and loading of Doxorubicin (DOX) to the HCNs, the HER2@HCNs/DOX can specifically access HER2-positive breast cancer cells and significantly suppress the cells in vitro, causing ∼60% reduction of the volume of the HER2-positive tumours in vivo. The HCNs show great promise to become a multifunctional carrier in the field of high-loading capacity drug delivery for cancer therapy.

Graphical abstract: Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Apr 2017, accepted on 17 May 2017 and first published on 17 May 2017


Article type: Paper
DOI: 10.1039/C7TB01105A
Citation: J. Mater. Chem. B, 2017,5, 6601-6607
  •   Request permissions

    Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

    L. Zhang, P. Wang, W. Zheng and X. Jiang, J. Mater. Chem. B, 2017, 5, 6601
    DOI: 10.1039/C7TB01105A

Search articles by author

Spotlight

Advertisements