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Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

Abstract

We present a novel style of hollow carbon nanospheres (HCNs) for targeted breast cancer therapy. The HCNs have a 40 nm-cavity for drugs loading and the surface are covered with “natural” primary amine without any exogenous modification and ready to conjugate with functional biomolecules. After modification with anti-HER2 antibody and loading of Doxorubicin (DOX) to the HCNs, the HER2@HCNs/DOX can specifically access HER2-positive breast cancer cells and lead to significant suppression of the cells in vitro and cause ~60 % reduction of the volume of the HER2-positive tumours in vivo. The HCNs show great promise to become a multifunctional carrier in the field of high-loading capacity drug delivery for cancer therapy.

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Publication details

The article was accepted on 17 May 2017 and first published on 17 May 2017


Article type: Paper
DOI: 10.1039/C7TB01105A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Hollow carbon nanospheres for targeted delivery of chemotherapeutics in breast cancer therapy

    L. Zhang, P. Wang, W. Zheng and X. Jiang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01105A

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