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Gold-Stabilized Carboxymethyl Dextran Nanoparticles for Image-Guided Photodynamic Therapy of Cancer

Abstract

Photodynamic therapy (PDT) has been extensively investigated to treat cancer since it induces cell death through the light activation of photosensitizers. However, its success has been hampered by the insufficient selectivity of photosensitizers to tumor tissues. In an attempt to increase the therapeutic efficacy of PDT by targeting the photosensitizer specifically to the tumor site, we prepared chlorin e6 (Ce6)-loaded gold-stabilized carboxymethyl dextran nanoparticles (Ce6-GS-CNPs). Ce6-GS-CNPs possessed highly stable nanostructures, by which their particle sizes were not significantly changed in the presence of serum for 6 days. When Ce6-GS-CNPs were intravenously injected into the tumor-bearing mice, they exhibited prolonged circulation in the body and gradually accumulated in the tumor tissue. Under laser irradiation to the tumor site which could be recognized by the near-infrared fluorescence imaging system, Ce6-GS-CNPs effectively suppressed the tumor growth. Overall, Ce6-GS-CNPs might have the potential as the nanomedicine for image-guided photodynamic cancer therapy.

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Publication details

The article was received on 21 Apr 2017, accepted on 01 Aug 2017 and first published on 03 Aug 2017


Article type: Paper
DOI: 10.1039/C7TB01099K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Gold-Stabilized Carboxymethyl Dextran Nanoparticles for Image-Guided Photodynamic Therapy of Cancer

    M. Lee, H. Lee, V. R. N, H. S. Han, S. Jeon, J. Jeon, S. Lee, S. Kwon, Y. D. Suh and J. H. Park, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01099K

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