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A series of terpyridine-based zinc(II) complexes assembling for third-order nonlinear optical response in the near-infrared region and recognizing lipid membranes

Abstract

Efficient utilization of near-infrared (NIR) photons as the excitation source for biomedical research is one of the most challenging missions. Herein, NIR-activated NLO optical materials, the terpyridine derivative ligand with a donor-acceptor (D-A) model and its corresponding four zinc(II) complexes (Z1-Z4) were assembled and fully characterized. Relying on their systematic photophysical investigations, it was found that the third-order NLO response in the near-infrared (NIR) region is significantly enhanced for the symmetrical complex Z4 compared to the other asymmetric complexes (Z1-Z3). To further explore the utility in biological system, Z4 was selected as a two-photon probe for cellular lipid membrane, which was confirmed with both by two-photon confocal microscopy and transmission electron microscopy (TEM). Furthermore, it was also found that the fluorescence intensity was enhanced for complex Z4 with the addition of bioactive liposomes (1 g•mL-1). Its recognition mechanism has been demonstrated by experimental methods, as well as molecular modeling calculations. The findings should open a new pathway for functional metal complexes as lipid membranes targeting probe.

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Publication details

The article was received on 19 Apr 2017, accepted on 26 Jun 2017 and first published on 26 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01063J
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    A series of terpyridine-based zinc(II) complexes assembling for third-order nonlinear optical response in the near-infrared region and recognizing lipid membranes

    Y. Tang, M. Kong, X. Tian, J. Wang, Q. Xie, A. Wang, Q. Zhang, H. Zhou, J. Wu and Y. Tian, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01063J

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