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Mesoporous Titanium Dioxide Nanocarrier with Magnetic-Targeting and High Loading Efficiency for Dual-Modal Imaging and Photodynamic Therapy

Abstract

Photodynamic therapy (PDT) through yielding reactive oxygen species (ROS) inhibit cancer cells is an emerging and pioneering cancer therapeutic modality to improve the drawbacks of other traditonal anticancer therapies. Herein, to combine NIR mediated PDT, chemotherapy and gene therapy in a synergy manner, a novel near-infrared (NIR) light activated photosensitizer for PDT based on TiO2-coated Fe3O4 nanoparticles core/shell nanocarriers (Fe3O4@TiO2@mTiO2) was designed, which was prepared to loading both chemotherapy drug DOX through pH-reversible hydrazone bond linking and β-catenin siRNA in the mesoporous. Fe3O4@TiO2@mTiO2-DOX/siRNA delivery systems have features functions of magnetic target, fluorescent imaging, MRI diagnosis, and combination therapy through the manoeuvre of a magnet and NIR mediated PDT. In vitro, Fe3O4@TiO2@mTiO2-DOX/siRNA effectively silences β-catenin gene, induces tumor cell apoptosis and consequently significantly enhances the cancer suppression effect of the synergy therapeutic agent. Meanwhile, under NIR irradiation, excessive ROS produced can further trigger tumor cell apoptosis. In vivo investigation confirmed that Fe3O4@TiO2@mTiO2-DOX/siRNA exhibited high tumor targeted specificity through MRI imaging and fluorescence imaging, and optimal anti-tumor efficacy. The results verified the significant therapeutic effects on tumors with the assistance of combination therapy consisting of magnetic target and NIR mediated PDT.

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Publication details

The article was received on 18 Apr 2017, accepted on 13 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01035D
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Mesoporous Titanium Dioxide Nanocarrier with Magnetic-Targeting and High Loading Efficiency for Dual-Modal Imaging and Photodynamic Therapy

    Q. Yu, J. Sun, X. Zhu, L. Qiu, M. Xu, S. liu, J. Ouyang and J. Liu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01035D

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