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Efficient Electrochemical Detection of Cancer Cells on in-situ Surface-Functionalized MoS2 Nanosheets

Abstract

Surface engineering is crucial to improve biocompatibility and sensing response of two-dimensional (2D) nanomaterials. For nanostructured MoS2 biosensors, post functionalization via cumbersome procedures unfortunately leads to inevitable structural damages and thus reduced functionalities. Herein, in-situ surface functionalization by the reactant of thiourea (TU) was employed to one-step fabricate TU-capped MoS2 (TU-MoS2) nanosheets. The amino-group terminated surface of TU-MoS2 benefits immobilizing GE11 peptide that can specifically recognize cancer cells. The resulting sensor shows high sensitivity and selectivity in detecting cancer cell, relying on the varied expression of epidermal growth factor receptor (EGFR) on cell membrane. In the case of human liver cancer cell, it is featured by a wide linear range (50 ~ 106 cells mL-1) and a low detection limit (50 cells mL-1) in electrochemical impedance spectroscopy, as the variation of charge-transfer resistance is ploted with cell concentration. Furthermore, it exhibits good efficiency to monitor dynamic variation of EGFR expression on living cells in response to drug treatment, which is promising for clinical diagnosis and drug screening in miniaturization. Elucidating an efficient biosensing platform on the basis of surface engineered MoS2 nanosheets, this work sheds some light on the development of biosensing technology and relevant materials.

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Publication details

The article was received on 14 Apr 2017, accepted on 14 Jun 2017 and first published on 17 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01024A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Efficient Electrochemical Detection of Cancer Cells on in-situ Surface-Functionalized MoS2 Nanosheets

    Y. Guo, Y. Shu, A. Li, B. Li, J. Pi, J. Cai, H. Cai and Q. Gao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01024A

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