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Zwitterionic copolymers bearing phosphonate or phosphonic motifs as novel metal-anchorable anti-fouling coatings

Abstract

Developing a facile but efficient anti-fouling surface coating is highly required for metallic implants. Here, we report two kinds of zwitterionic copolymers (both random and block) that bearing phosphonic/phosphonate motifs/segment as novel metal anchorable antifouling coatings. Through conventional free radical polymerization and reversible addition–fragmentation chain transfer (RAFT) polymerization, three types of zwitterionic-phosphonic random copolymers with varied mol. ratios (9:1, 8:2, and 6:4) and a phosphonate-zwitterionic block polymer, were precisely prepared based on zwitterionic sulfobetaine methacrylate (SBMA) and phosphonate/phosphonic methacrylate. As evidenced by XPS and water contact angle tests, the two kinds of copolymers with distinguished presenting manners of the metal-anchorable phosphonate/phosphonic motifs were all successfully immobilized on the Ti substrates through a facile one-step post-functionalization. The immobilized copolymers equally exhibited strong inhibition of protein adsorption and platelet adhesion, endowing significantly improved antifouling ability to the metallic substrates. This work not only provides a novel approach to improve the antifouling ability of Ti substrates, the utilization of phosphonic/phosphonate based copolymers as the efficient metal-anchorable coatings may offer a new platform for versatile surface functionalization of many metallic substrates.

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Publication details

The article was received on 13 Apr 2017, accepted on 06 Jun 2017 and first published on 06 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01017F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Zwitterionic copolymers bearing phosphonate or phosphonic motifs as novel metal-anchorable anti-fouling coatings

    T. Huang, H. Liu, P. Liu, P. Liu, L. Li and J. shen, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01017F

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