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Alkylated branched poly(β-amino esters) demonstrate strong DNA encapsulation, high nanoparticle stability and robust gene transfection efficacy

Abstract

A branched poly(β-amino ester) with numerous alkyl chains (BPA) is designed and synthesized as a safe and efficient non-viral vector. The branching and hydrophobicity synergistically impart BPA with tight DNA condensation, high polyplex stability in serum, high cellular uptake and ultimately robust gene transfection efficiency, largely superior to its linear counterpart (LPA). Our results demonstrate branching matters for gene delivery by hydrophobic gene vectors.

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Publication details

The article was received on 11 Apr 2017, accepted on 14 Jun 2017 and first published on 16 Jun 2017


Article type: Communication
DOI: 10.1039/C7TB00996H
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Alkylated branched poly(β-amino esters) demonstrate strong DNA encapsulation, high nanoparticle stability and robust gene transfection efficacy

    S. Liu, Z. Sun, D. Zhou and T. Guo, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00996H

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