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Issue 30, 2017
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Packaging cordycepin phycocyanin micelles for the inhibition of brain cancer

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Abstract

Cordycepin has been successfully used as a natural anti-cancer drug, but it is rapidly metabolized in vivo. Nanoencapsulation is thus a promising method to improve its bioavailability. In this study, we adopted a green synthesis process to develop novel self-assembling phycocyanin–dextran–cordycepin (Phy–Dex–Cord) micelles for efficient cordycepin encapsulation and delivery. We first used the Maillard reaction method to graft dextran onto phycocyanin, forming a phycocyanin–dextran complex. Through the self-assembly of the cordycepin parcel to the phycocyanin–dextran complex, the micelles were formed. Their physical and chemical properties and characterization results showed that Phy–Dex–Cord micelles have a spherical shape and consistent size distribution of about 60 nm. In addition, anti-cancer activities in vitro and in vivo revealed that the Phy–Dex–Cord micelles have a comparable or even stronger inhibitory effect against C6 cells than do free cordycepin and free phycocyanin and no side effects.

Graphical abstract: Packaging cordycepin phycocyanin micelles for the inhibition of brain cancer

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Publication details

The article was received on 11 Apr 2017, accepted on 27 Jun 2017 and first published on 28 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00994A
Citation: J. Mater. Chem. B, 2017,5, 6016-6026
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    Packaging cordycepin phycocyanin micelles for the inhibition of brain cancer

    M. Zhao, L. Chen, W. Chen, Z. Meng, K. Hu, S. Du, L. Zhang, L. Yin, B. Wu and Y. Guan, J. Mater. Chem. B, 2017, 5, 6016
    DOI: 10.1039/C7TB00994A

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