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Synthesis of water-soluble and highly fluorescent gold nanoclusters for Fe3+ sensing in living cells using fluorescence imaging

Abstract

Gold nanoclusters are used as an excellent scaffolds for the development of chemical and biological sensors due to their outstanding physical and chemical properties. In this study, a facile and green methodhas employed for preparation of highly flurescent Au NCs by simply heating the gold precusor solution in presence of specially designed multidentate polymer ligands PTMP-PMAA. Herein, PTMP-PMAA function as a reducing agent as well as a protecting agent. The Au NCs were characterized by fluorescence spectroscopy, ultraviolet absorption spectroscopy, dynamic light scattering (DLS), X-ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), powder X-ray diffraction (PXRD) and found to exhibit yellow fluorescence (em=553 nm), a high quantum yield (22.6%), excellent stability and water-solubility. Based on the aggregation-induced fluorescence quenching, the Au NCs@PTMP-PMAA fluorescent NCs were used for the dectection of Fe3+ with an acceptable sensitivity having a detection limit of 3.0 μM and high selectivity. Moreover, Au NCs were also explored for fluorescence imaging Fe3+ in living H9c2 cardiac musle cells presenting an internalization with a green fluorescence from the cells, suggesting their potential applicability as a biomaging agent.

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Publication details

The article was received on 07 Apr 2017, accepted on 14 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00966F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Synthesis of water-soluble and highly fluorescent gold nanoclusters for Fe3+ sensing in living cells using fluorescence imaging

    J. Zhang, C. Cai, S. Razzaque, I. Hussain, Q. Lu and B. Tan, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00966F

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