Issue 29, 2017

PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

Abstract

Three ruthenium(II) phthalocyanines functionalized at their axial positions with 4–12 PEG chains bearing hydroxy, amino and ether terminal groups were synthesized and studied as PDT agents against bladder cancer cells. All three dyes displayed high singlet oxygen generation quantum yields in DMSO (ΦΔ = 0.76). The water-soluble Ru(L3)2Pc also shows high singlet oxygen quantum yields (ΦΔ = 0.48) in neat water. In vitro studies show that these complexes are accumulated in bladder cancer cells, are nontoxic PSs per se, and have high phototoxic efficiency.

Graphical abstract: PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

Supplementary files

Article information

Article type
Paper
Submitted
06 Apr 2017
Accepted
22 Jun 2017
First published
22 Jun 2017

J. Mater. Chem. B, 2017,5, 5862-5869

PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

J. Teles Ferreira, J. Pina, C. Alberto Fontes Ribeiro, R. Fernandes, J. P. C. Tomé, M. S. Rodríguez-Morgade and T. Torres, J. Mater. Chem. B, 2017, 5, 5862 DOI: 10.1039/C7TB00958E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements