Jump to main content
Jump to site search


PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

Author affiliations

Abstract

Three ruthenium(II) phthalocyanines functionalized at their axial positions with 4–12 PEG chains bearing hydroxy, amino and ether terminal groups were synthesized and studied as PDT agents against bladder cancer cells. All three dyes displayed high singlet oxygen generation quantum yields in DMSO (ΦΔ = 0.76). The water-soluble Ru(L3)2Pc also shows high singlet oxygen quantum yields (ΦΔ = 0.48) in neat water. In vitro studies show that these complexes are accumulated in bladder cancer cells, are nontoxic PSs per se, and have high phototoxic efficiency.

Graphical abstract: PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Apr 2017, accepted on 22 Jun 2017 and first published on 22 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00958E
Citation: J. Mater. Chem. B, 2017, Advance Article
  •   Request permissions

    PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

    J. Teles Ferreira, J. Pina, C. Alberto Fontes Ribeiro, R. Fernandes, J. P. C. Tomé, M. S. Rodríguez-Morgade and T. Torres, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00958E

Search articles by author

Spotlight

Advertisements