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Topology Dictates Function: Controlled ROS Production and Mitochondria Accumulation via Curved Carbon Materials

Abstract

Both reactive oxygen species (ROS) and mitochondria are involved in many physiological and pathological processes. We employed curved corannulene with a large dipole moment for controlled ROS production and mitochondria targeting. Corannulene was solubilized in water via complexing with gama-cyclodextrin (1:2). The complex could produce type I ROS in water in a dose- and irradiation time-dependent manner. It is the curvature-induced dipole moment that could aid electron transfer and hence enable ROS generation. As a consequence of electron delocalization that facilitates its mitochondrial uptake by a large membrane potential, the mitochondrial accumulation of corannulene was demonstrated. However, this is not valid for flat perylene control. This discovery will not only present a new tool for controlled ROS production as well as mitochondria targeting to serve the basic biomedical research, but also opens the avenue for potential application of curved carbon materials as therapeutic agents.

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Publication details

The article was received on 06 Apr 2017, accepted on 15 May 2017 and first published on 16 May 2017


Article type: Paper
DOI: 10.1039/C7TB00954B
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Topology Dictates Function: Controlled ROS Production and Mitochondria Accumulation via Curved Carbon Materials

    S. Liu, D. Lu, X. Wang, D. Ding, D. Kong, Z. Wang and Y. Zhao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00954B

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