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Encapsulation of Au/Fe3O4 nanoparticles into polymer nanoarchitecture with combined near infrared-triggering chemo-photothermal therapy based on intracellular secondary protein understanding

Abstract

The combination of the functions of near infrared-triggering molecule release and chemo-photothermal therapy improved the therapeutic effect, but clarifying of the cancer damage pathway in protein molecule levels has yet to well study. In this study, we developed a polymer encapsulation synthesis of Au/Fe3O4@polymer nanoparticles as swiss army knife to integrate near infrared absorption, magnetism, and doxorubicin (DOX) loading ability into a single package. By exposing to near infrared absorption, Au/Fe3O4@polymer nanoparticles possessed photothermal therapy, making anti-tumor growth suppression of HT-29 tumor-bearing nude mice with less body weight loss. For deeply understanding the interactions between drug-loaded nanocarriers and protein structures of treated cells, delivering therapeutic DOX agent combined with photothermal therapy with Au/Fe3O4@polymer nanostructures to cancer cells was investigated. Synchrotron-based FTIR imaging and confocal imaging showed direct observation of the efficient photo-chemotherapy impacting on MCF7, MCF7/ADR, and HT-29 cells after the near infrared radiation-triggered DOX release. Our demonstration outlines how the cell destruction in molecular mechanism initiated by chemo-photothermal combination therapy after the translocation of DOX from cytosol to nuclei, leading to alter intracellular secondary protein. For pre-clinical application of potential diagnosis to cancer cells, Au/Fe3O4@polymer nanoparticles performed integrated computed tomography/magnetic resonance imaging contrast enhancement and near infrared-triggering chemo-photothermal therapy

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Publication details

The article was received on 05 Apr 2017, accepted on 19 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00944E
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Encapsulation of Au/Fe3O4 nanoparticles into polymer nanoarchitecture with combined near infrared-triggering chemo-photothermal therapy based on intracellular secondary protein understanding

    C. Chen, W. Syu, T. Huang, Y. Lee, J. Hsiao, K. Huang, H. Yu, M. Liao and P. Lai, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00944E

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