Jump to main content
Jump to site search

Issue 24, 2017
Previous Article Next Article

Tailoring La1−xSrxMnO3 (0.25 ≤ x ≤ 0.35) nanoparticles for self-regulating magnetic hyperthermia therapy: an in vivo study

Author affiliations

Abstract

A careful design of La1−xSrxMnO3 (0.25 ≤ x ≤ 0.35) nanoparticles (NPs) was made to prepare a self-controlled heating agent for magnetic hyperthermia therapy (MHT). The results showed that the magnetic properties and heating efficacy of the tailored La1−xSrxMnO3 NPs are strongly dependent on the doping level of La/Sr cations, so that La0.73Sr0.27MnO3 NPs possessed the highest saturation magnetization and heating efficacy in response to safe alternating magnetic fields used in biomedical applications (H = 3.4–5.0 mT and f = 120 kHz). Furthermore, to improve the biocompatibility of the La0.73Sr0.27MnO3 NPs, the surface of the NPs was coated with a thin silica shell, and then the therapeutic efficacy of MHT using the silica-coated La0.73Sr0.27MnO3 NPs was investigated using a typical animal model of breast cancer. The results showed that in the control group, the mean tumor volume increased up to 300% over 6 days, while in the MHT group, the mean tumor volume decreased about 85% during the same period of time (Pvalue = 0.002). The outcomes of this study indicate that silica-coated La0.73Sr0.27MnO3 NPs are a promising tool for self-regulating MHT.

Graphical abstract: Tailoring La1−xSrxMnO3 (0.25 ≤ x ≤ 0.35) nanoparticles for self-regulating magnetic hyperthermia therapy: an in vivo study

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Apr 2017, accepted on 15 May 2017 and first published on 15 May 2017


Article type: Paper
DOI: 10.1039/C7TB00922D
Citation: J. Mater. Chem. B, 2017,5, 4705-4712
  •   Request permissions

    Tailoring La1−xSrxMnO3 (0.25 ≤ x ≤ 0.35) nanoparticles for self-regulating magnetic hyperthermia therapy: an in vivo study

    M. Soleymani, M. Edrissi and A. M. Alizadeh, J. Mater. Chem. B, 2017, 5, 4705
    DOI: 10.1039/C7TB00922D

Search articles by author

Spotlight

Advertisements