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A mussel-Inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure

Abstract

Injectable hydrogels are promising candidates for adhesives because of their ease of administration, minimal invasion, and biocompatibility. While developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility has still been a significant challenge. Herein, inspired from nature, we report a novel mussel-inspired tissue-adhesive hydrogel composed of poly(γ-glutamic acid) and dopamine (γ-PGA-DA) that can bond tissues well and stop bleeding in a wet environment by improving its tissue adhesiveness via a horseradish peroxidase-mediated reaction. The hydrogel exhibited 10–12 folds stronger wet tissue adhesion strength (58.2 kPa) over the clinically used fibrin glue and more effective hemostatic ability following liver impale in animal models (41.2% reduction in the average amount of bleeding compared with fibrin glue). In addition, the hydrogels demonstrated controlled gelation time, swelling ratio, microscopic morphology, biodegradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility. Overall results suggest that the γ-PGA-DA hydrogels can be considerably applied as promising wet-resistant adhesives and hemostasis.

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Publication details

The article was received on 24 Mar 2017, accepted on 14 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB00813A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    A mussel-Inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure

    W. Chen, R. Wang, T. Xu, X. Ma, Z. Yao, B. CHI and H. Xu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00813A

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