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C60@lysozyme: a new photosensitizing agent for photodynamic therapy

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Abstract

C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy. The reactive oxygen species (ROS) concentration generated by C60@lysozyme during irradiation depends on the light source, the irradiation time and the concentration of the hybrid. C60@lysozyme significantly reduced the HeLa cell viability in response to visible light irradiation. The generation of H2O2, due to the photoactivity of C60@lysozyme, causes cell death via easy permeation of hydrogen peroxide through the cell membrane and activation of endogenous ROS production.

Graphical abstract: C60@lysozyme: a new photosensitizing agent for photodynamic therapy

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Publication details

The article was received on 23 Mar 2017, accepted on 27 Apr 2017 and first published on 27 Apr 2017


Article type: Paper
DOI: 10.1039/C7TB00800G
Citation: J. Mater. Chem. B, 2017, Advance Article
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    C60@lysozyme: a new photosensitizing agent for photodynamic therapy

    A. Soldà, A. Cantelli, M. Di Giosia, M. Montalti, F. Zerbetto, S. Rapino and M. Calvaresi, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00800G

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