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Issue 20, 2017
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Manganese-iron layered double hydroxide: a theranostic nanoplatform with pH-responsive MRI contrast enhancement and drug release

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Abstract

Stimuli-responsive theranostic platforms are highly desirable for efficient cancer treatment because of their improved specificity and sensitivity. In this work, we report a manganese-iron layered double hydroxide (MnFe-LDH) for the first time and demonstrate that it can serve as a pH-responsive nanoplatform for cancer theranostics. The MnFe-LDH can respond to the acidic microenvironment of solid tumors to release paramagnetic Mn2+ and Fe3+ ions, resulting in great enhancement of the T1 MRI contrast of the tumor area. In addition, the layered structure enables MnFe-LDH to effectively deliver chemotherapeutic drugs in a pH-controlled manner, and therefore it can simultaneously inhibit the growth of solid tumors. We believe that this novel MnFe-LDH with pH-responsive property holds great promise in cancer theranostic applications.

Graphical abstract: Manganese-iron layered double hydroxide: a theranostic nanoplatform with pH-responsive MRI contrast enhancement and drug release

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Publication details

The article was received on 22 Mar 2017, accepted on 06 May 2017 and first published on 08 May 2017


Article type: Communication
DOI: 10.1039/C7TB00794A
Citation: J. Mater. Chem. B, 2017,5, 3629-3633
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    Manganese-iron layered double hydroxide: a theranostic nanoplatform with pH-responsive MRI contrast enhancement and drug release

    G. Huang, K. Zhang, S. Chen, S. Li, L. Wang, L. Wang, R. Liu, J. Gao and H. Yang, J. Mater. Chem. B, 2017, 5, 3629
    DOI: 10.1039/C7TB00794A

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